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2024;326(4):E472EE80

In recent years, we have witnessed a paradigm shift in cardiometabolic medicine: The SELECT trial demonstrated that GLP-1 receptor agonists reduce cardiovascular events even in patients without diabetes

[Abstract]2024 Sep 16:pyae040

A search for ligand binding sites with the docking program Molecular Operating Environment identified the ordered water network binding site, lined mainly with hydrophobic residues, suggesting an extended ligand binding surface for nonsubstrate ligands, the so-called ligandin site

Patients were randomised to 12 treatment regimens (eight lixisenatide and four volume-matched placebo groups) given OD within 1 h before breakfast or BD within 1 h before breakfast and dinner for 13 weeks of treatment